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Molecular structure visual for PFAS analysis
 
Research Chemicals

Chromasolv™ LC-MS Solvents
for PFAS Analysis

High-purity LC-MS solvents engineered to eliminate PFAS background noise — so your PFAS analytical workflows reflect your sample, not your solvent.

Acetonitrile
LC-MS for PFAS Analysis
Methanol
LC-MS for PFAS Analysis
Water
LC-MS for PFAS Analysis
Understanding PFAS

What is PFAS analysis?

Per- and polyfluoroalkyl substances (PFAS) are a broad class of thousands of chemically distinct compounds that vary widely in structure, environmental behavior, and properties. Some have been widely used in industrial processes and consumer products; some have been detected in water, soil, and biological samples.

Because PFAS encompasses such a diverse range of substances, accurate compound-specific analysis is essential. Laboratories, regulators, and researchers rely on PFAS analytical methods to identify which specific compounds are present, at what concentrations, and in what matrices. High-quality analytical data supports sound, science-based decision-making, whether for environmental monitoring, product stewardship, regulatory compliance, or research into the distinct characteristics of individual PFAS substances.

Chromasolv™ PFAS Workflow

Chromasolv™ LC-MS solvents support PFAS detection across the full environmental cycle — from soil, surface water and groundwater through to consumer products.


Specific testing environments

Learn more about specific testing


Solstice Advantage

Why ultra-low background matters

Chromasolv™ high-purity solvents are engineered to remove these obstacles. Backed by more than a century of innovation legacy as Burdick & Jackson™ and Riedel-de Haën™, Chromasolv™ is manufactured under rigorous quality control to deliver the stability and ultra-low background noise that modern chromatography demands. Every lot undergoes stringent specification testing, to ensure uniform composition and reproducible results.

An ultra-low PFAS background in LC-MS solvents is particularly important for short-chain compound analysis, where regulatory reporting limits may approach the detection capabilities of the instrument itself. At those concentrations, solvent-derived signal can become indistinguishable from sample-derived signal, compromising data quality and potentially requiring costly retesting. Chromasolv solvents are evaluated to minimize this interference across a broad range of target analytes.

Short-chain PFAS compounds can be present at trace levels in solvents, labware, and LC-MS system components. When solvent-derived signal overlaps with sample-derived signal, it becomes difficult to attribute detected concentrations to the sample with confidence, potentially leading to inflated results or repeated analysis. Chromasolv solvents for PFAS analysis are lot-tested against a defined panel of short-chain PFAS analytes, providing laboratories with documented baseline data to support reliable, reproducible results.
Many PFAS methods target ng/L (ppt) or lower detection limits. Background contamination elevates the baseline noise, directly increasing limits of detection (LOD) and quantitation (LOQ), making it difficult to confidently detect low-level PFAS. By ensuring every lot of Solstice solvents have ultra-low background, you can test with the sensitivity you need.
Short-chain PFAS analytes tend to be more water-soluble than their long-chain counterparts, which can make them more susceptible to carryover from solvents and mobile phases between injections.
Clean solvents support method compliance and ensure defensible data for regulatory reporting, litigation, and risk assessment. Solstice solvents have been tested using EPA 1633A and ASTM D7979 standards but go beyond compliance by testing for ultra-low background levels in every lot.

Using ultra-low PFAS LC-MS solvents is essential to maintain low background noise, achieve reliable detection at trace levels, and ensure the accuracy and credibility of PFAS analytical results.


Our Products

Chromasolv™ LC-MS Solvents for PFAS Analysis

Available in the following bottles: 1L 45mm opening, 2.5L 45mm opening, and 4L sold by the case.

Methanol Catalog IDs
CAS #67-56-1
39290-6x1GL
39290-4x2.5GL
39290-4x4L
Acetonitrile Catalog IDs
CAS #75-05-8
39291-6x1GL
39291-4x2.5GL
39291-4x4L
Water Catalog IDs
CAS #7732-18-5
39292-6x1GL
39292-4x2.5GL
39292-4x4L

Additional solvents, bottle sizes and packaging configurations may be available upon request.

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Resources

Chromasolv — Clear Separations, Pure and Simple

In chromatography, clarity is everything. Yet even trace impurities, baseline noise, or lot-to-lot variability in solvents can obscure peaks, compromise sensitivity, and introduce uncertainty into results. As analytical methods grow more sensitive and complex, particularly in HPLC, GC, and LC-MS workflows, scientists need solvents that perform consistently at the limits of detection. When solvent quality can’t keep pace with modern instrumentation, labs lose time and can’t trust their data.

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SOLSTICE LABREADY™

FOR CUSTOM BLENDS

No matter your application, our expert team can work with yours to develop, test, manufacture, and package custom blends and unique formulations.